Abstract
At present, there is no efficient treatment to prevent the evolution of Parkinson’s disease (PD). PD is generated by the concurrent activity of multiple factors, which is a serious obstacle for the development of etio-pathogenic treatments. Astrocytes may act on most factors involved in PD and the promotion of their neuroprotection activity may be particularly suitable to prevent the onset and progression of this basal ganglia (BG) disorder. The main causes proposed for PD, the ability of astrocytes to control these causes, and the procedures that can be used to promote the neuroprotective action of astrocytes will be commented upon, here.
Highlights
Progress of Parkinson’s Disease.Parkinson’s disease (PD) is produced by the confluence of multiple circumstances that, acting together, accelerate an aging-related degeneration of the nigrostriatal dopaminergic cells (DA-cells) and of other neuronal populations [1]
There is a growing interest in studying the involvement of astrocytes in the etiopathogenesis of PD, but their actual role remains unclear. Astrocytes may both protect and damage neurons, and it has been suggested that they prevent the onset and accelerate the progression of PD
The first part of the review presents a summary view of the main causes involved in the DA-cell degeneration, discussing how astrocytes can influence them either by preventing or promoting their activity
Summary
Parkinson’s disease (PD) is produced by the confluence of multiple circumstances that, acting together, accelerate an aging-related degeneration of the nigrostriatal dopaminergic cells (DA-cells) and of other neuronal populations [1]. There is a growing interest in studying the involvement of astrocytes in the etiopathogenesis of PD, but their actual role remains unclear. Astrocytes may both protect and damage neurons, and it has been suggested that they prevent the onset and accelerate the progression of PD. The first part of the review presents a summary view of the main causes involved in the DA-cell degeneration, discussing how astrocytes can influence them either by preventing (slowing the PD progression) or promoting (accelerating the PD onset/progression) their activity.
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