Abstract
This study discovers a previously unrecognized role of AEG-1 in GSC biology and supports the significance of this gene as a potential therapeutic target for glioblastoma multiforme. Mol Cancer Res; 15(2); 225-33. ©2016 AACR.
Highlights
Glioblastoma multiforme is the most prevalent and aggressive cancer of the central nervous system
After cell sorting with the CD133 cell surface marker, the majority of Astrocyte elevated gene (AEG)-1 protein was associated with the CD133þ cell population in primary glioblastoma multiforme neurospheres VG2 and VG9 (Fig. 1B; Supplementary Fig. S2)
Overexpression of AEG-1 using adenovirus transduction in CD133À glioma cells enhanced the expression of glioma stem cell markers, including CD133, SOX2, and tumor mesenchymal marker CD44, which were detected at both protein and mRNA levels (Fig. 1C and D)
Summary
Glioblastoma multiforme is the most prevalent and aggressive cancer of the central nervous system. Glioblastoma multiforme is highly proliferative, invasive, and vascular and is considered one of the most lethal human cancers. Despite the combination of surgery, chemotherapy, and radiotherapy, improvements in patient outcome have only improved modestly in the past decades, which highlight the dire need for an effective treatment of these aggressive tumors [1,2,3]. Cancer stem-like (CSC) cells represent a population of rare tumor cells characterized by their ability to self-renew and to induce tumorigenesis [4,5,6]. Glioma-like stem cells (GSC) have been isolated from both human brain tumors and several glioma. Note: Supplementary data for this article are available at Molecular Cancer Research Online (http://mcr.aacrjournals.org/).
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