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Abstract
Astragaloside IV (AS-IV) is one of the major bio-active ingredients of huang qi which is the dried root of Astragalus membranaceus (a traditional Chinese medicinal plant). The pharmacological effects of AS-IV, including anti-oxidative, anti-cancer, and anti-diabetic effects have been actively studied, however, the effects of AS-IV on liver regeneration have not yet been fully described. Thus, the aim of this study was to explore the effects of AS-IV on regenerating liver after 70% partial hepatectomy (PHx) in rats. Differentially expressed mRNAs, proliferative marker and growth factors were analyzed. AS-IV (10 mg/kg) was administrated orally 2 h before surgery. We found 20 core genes showed effects of AS-IV, many of which were involved with functions related to DNA replication during cell division. AS-IV down-regulates MAPK signaling, PI3/Akt signaling, and cell cycle pathway. Hepatocyte growth factor (HGF) and cyclin D1 expression were also decreased by AS-IV administration. Transforming growth factor β1 (TGFβ1, growth regulation signal) was slightly increased. In short, AS-IV down-regulated proliferative signals and genes related to DNA replication. In conclusion, AS-IV showed anti-proliferative activity in regenerating liver tissue after 70% PHx.
Highlights
For a long time, medicinal plants have played a key role in pharmacological research studies and drug development
The Astragaloside IV (AS-IV) group showed a low expression of Hepatocyte growth factor (HGF)
We investigated the effects of AS-IV on liver regeneration in a 70% PHx model using mRNA sequencing, immunohistochemistry, and Western blot analysis
Summary
Medicinal plants have played a key role in pharmacological research studies and drug development. Astragalus membranaceus is medicinal plant that has been used in traditional Chinese medicine throughout history; it is called Astragali Radix. Huang qi (黃芪, in Chinese) is the name for the dried root of Astragalus membranaceus and it is mainly produced in China, Mongolia, and Korea [1]. The main components of huang qi are saponins, polysaccharides and flavonoids [2,3,4]. It has been used in traditional Chinese medicine for over 2000 years to treat various diseases including anemia, cardiovascular disorder, weakness, fatigue and fever [4,5]. It has been reported that huang qi has anti-oxidative, anti-aging, anti-inflammatory, anti-diabetic, and anti-cancer properties [1,2,3,4]
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