Abstract
There is an association between sensitisation to moulds, uncontrolled fungal infections and bad asthma control. The diagnosis of allergic broncho-pulmonary aspergillosis (ABPA) is based on three indispensible criteria: a reversible ventilatory disorder or mucoviscidosis, a total IgE > 1000 UI / ml ml and a specific Aspergillus IgE> 0,35 KUA /l, associated with two of the following: a positive Aspergillus precipintin test, a characteristic CT-scan and a blood eosinophilia > 500 cells / μ moL (without taking corticoids). The treatment is based on reduction of the local inflammation by systemic corticoids and on the decrease of mycelial proliferation during exacerbations by Itraconazole. The prevalence of severe asthma with fungal sensitisation (SAFS) is about 30 % and the use of azoles should be time-limited and reserved for refractory situations in severe asthma.
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