ASTHMA;

Abstract

The aim on the study was to compare the efficancy of salmeterol and formoterolin persistent asthama. Study Design: Randomized-Controlled-Trial(RCT). Setting: Departmentof Medicine, Allied Hospital, Faisalabad. Period: June 2014 to December 2014. Methodology:Patients of both genders with ages between 18 and 70 years having persistent bronchial asthmawhile Pregnant or lactating mothers, patients with upper or lower respiratory tract infections,acute asthma exacerbations within 4 weeks of first visit, Oral corticosteroids within 4 weeks ordepot steroids within 12 weeks of first visit and Smoking history of more than 10 pack yearswere excluded from study. Patients were randomly divided into two groups (Group A & GroupB) using computer generated random number table. Salmeterol/Fluticasone combination wasgiven to group A with a dose of 50/250μg, 2 actuations with ABEL SPACER DEVICE twice aday for a period of 24 weeks. Formoterol/Budesonide combination was given to group B with adose of 400/6μg with Rotahaler twice a day. Follow up was done by patient’s outdoor visits at6th,12th,18h and 24th week. Results: 180 patients were enrolled in the study. 79 (44%) weremales and 101 (56%) were females. Mean age of study population was 45.25+13.382 years.Patients in Group B experienced lesser number of exacerbations than patients in Group B.Group B showed better response to treatment than Group A using chi square test. (P-Value0.001). Conclusion: It has been concluded that budesonide/Formoterol is more effective incontrolling asthma symptoms than fluticasone/Salmeterol.