Abstract
BackgroundThe increase in asthma rates has been linked epidemiologically to the rapid disappearance of Helicobacter pylori, a bacterial pathogen that persistently colonizes the human stomach. Recent evidence indicates that, H. pylori may have protective effects on allergic diseases. ObjectiveThe aim of this study was to explore the relationship between asthma and H. pylori infection in a population with high prevalence of H. pylori infection. Patients and methodsOne hundred and seventeen asthma cases were eligible for the study in addition to 86 non asthma cases as control. Pre and post – bronchodilator spirometry, assay of Total serum immunoglobulin E (IgE) by enzyme immunoassay technique (ELISA) and 14C Urea Breath Test (UBT) were done. Out of 41 asthmatic cases with positive H. pylori were 22 patients had mild asthma, 14 had moderate asthma, and 5 only had severe asthma with statistically significant difference between them. ResultsThe mean serum level of Total IgE was significantly higher (190.04±111.9) in patients group than control group (94.13±46.49) with p-value 0.000, while the mean UBT was significantly lower (325.85±261.35) in patients group than control group (1068.67±680.7) with p-value 0.000. AS regard pulmonary function tests (FEV1 and FVC), there was statistically significant difference between positive H. pylori asthmatic and negative H. pylori asthmatic. ConclusionWe demonstrate an inverse association between H. pylori and asthma in a population with a high prevalence of H. pylori.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Egyptian Journal of Chest Diseases and Tuberculosis
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
