Assosiation of angiopoietin-like protein 2 to lower extremity arterial disease in type 2 diabetes mellitus

Abstract

Objective To study the assosiation of angiopoietin-like protein 2(ANGPTL2) to lower extremity arterial disease in type 2 diabetes mellitus. Methods A total of 360 type 2 diabetic patients were divided into three groups: without(group A), with mild to moderate(group B), and severe(group C) lower extremity arterial disease according to the ankle brachial index. And, 120 healthy subjects serveed as control group. The levels of ANGPTL2, high sensitivity C-reactive protein(hsCRP), free fatty acid, biochemical index, and fasting insulin were detected. And, waist-to-hip ratio(WHR), body mass index(BMI), insulin resistance index were calculated. Results The level of ANGPTL2 was getting higher and higher as lower extremity arterial disease progressing. The level of ANGPTL2 in group B was higher than that in group A[1.27(1.09, 1.51)vs 0.88(0.66, 1.07)μg/L, P<0.05], and the level of ANGPTL2 in group C was higher than that in group B[1.70(1.45, 1.91)vs 1.27(1.09, 1.51)μg/L, P<0.05]. Pearson correlation analysis showed that the ANGPTL2 level in serum positively correlated with hsCRP, BMI, WHR, cholesterol, low-density lipoprotein-cholesterol, fasting insulin, and insulin resistance index. Logistic regression analysis showed that the levels of ANGPTL2, hsCRP, and glycosylated hemoglobin were significantly associated with lower extremity arterial disease in type 2 diabetes mellitus. Conclusion It is possible that ANGPTL2 is one of the risk factors of lower extremity arterial disease in type 2 diabetes mellitus, and which is likely to be of great significance in the early prediction, disease assessment, and prognosis evaluation for lower extremity arterial disease in type 2 diabetes mellitus. (Chin J Endocrinol Metab, 2015, 31: 872-876) Key words: Angiopoietin-like protein 2; Diabetes mellitus, type 2; Lower extremity arterial diseases