Abstract
Background:Features of the urban physical environment may be linked to the development of high blood pressure, a leading risk factor for global burden of disease.Objectives:We examined associations of urban physical environment features with hypertension and blood pressure measures in adults across 230 Latin American cities.Methods:In this cross-sectional study we used health, social, and built environment data from the SALud URBana en América Latina (SALURBAL) project. The individual-level outcomes were hypertension and levels of systolic and diastolic blood pressure. The exposures were city and subcity built environment features, mass transit infrastructure, and green space. Odds ratios (ORs) and mean differences and 95% confidence intervals (CIs) were estimated using multilevel logistic and linear regression models, with single- and multiple-exposure models adjusted for individual-level age, sex, education, and subcity educational attainment.Results:A total of 109,176 participants from 230 cities and eight countries were included in the hypertension analyses and 50,228 participants from 194 cities and seven countries were included in the blood pressure measures analyses. Participants were 18–97 years of age. In multiple-exposure models, higher city fragmentation was associated with higher odds of having hypertension (; 95% CI: 1.01, 1.21); presence (vs. no presence) of mass transit in the city was associated with higher odds of having hypertension (; 95% CI: 1.09, 1.54); higher subcity population density was associated with lower odds of having hypertension (; 95% CI: 0.85, 0.94); and higher subcity intersection density was associated with higher odds of having hypertension [; 95% CI: 1.04, 1.15). The presence of mass transit was also associated with slightly higher systolic and diastolic blood pressure in multiple-exposure models adjusted for treatment. Except for the association between intersection density and hypertension, associations were attenuated after adjustment for country. An inverse association of greenness with continuous blood pressure emerged after country adjustment.Discussion:Our results suggest that urban physical environment features—such as fragmentation, mass transit, population density, and intersection density—may be related to hypertension in Latin American cities. Reducing chronic disease risks in the growing urban areas of Latin America may require attention to integrated management of urban design and transport planning. https://doi.org/10.1289/EHP7870
Highlights
High systolic blood pressure is a leading risk factor for global burden of disease and has been estimated to be responsible for >10 million deaths and >200 million disability-adjusted life years (GBD 2017 Risk Factor Collaborators 2018)
The study sample for hypertension analyses included 109,176 individuals distributed in 230 cities with a median of 343 respondents per city
The study sample for blood pressure analyses included 50,228 individuals distributed in 194 cities with a median of 68 respondents per city
Summary
High systolic blood pressure is a leading risk factor for global burden of disease and has been estimated to be responsible for >10 million deaths and >200 million disability-adjusted life years (GBD 2017 Risk Factor Collaborators 2018). High blood pressure has been identified as one of the most important modifiable risk factor for cardiovascular disease morbidity and mortality worldwide (Olsen et al 2016). The population impact of high blood pressure is increasing because of longer life expectancy (Olsen et al 2016). A few studies have suggested that features of the urban physical environment may be linked to higher blood pressure and higher cardiovascular risk. Features of the urban physical environment may be linked to the development of high blood pressure, a leading risk factor for global burden of disease
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