Abstract
Background Identification and intervention of insulin resistance may be beneficial to the prevention of hyperuricemia (HUA) and its related diseases. Thus, we conducted this longitudinal study to examine the relation of triglyceride-glucose index (TyG), a simple noninsulin-based IR assessment tool, and its derivatives with the risk of HUA. Methods A total of 42,387 adults who received routine health screening and were free of HUA were included for the longitudinal analyses. TyG, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WtHR) were calculated through anthropometric and biochemical indicators. Associations of TyG, TyG-BMI, TyG-WC, and TyG-WHtR with HUA risk were estimated using Cox regression analyses. Results The incident cases of HUA occurred in 4,230 subjects during the 138,163 person-years of observation, and the crude incidence rate of HUA was 30.6 per 1000 person-years. After multivariate adjustment, we observed an increased risk for incident HUA for the upper TyG and its derivatives' tercile. The HRs of TyG were greater than that of its components in both sexes. Compared with TyG, TyG-related parameters only had higher HRs in women but not in men. Conclusions TyG and its integration with obesity indicators have the potential to help risk stratification and prevention of HUA, especially among women.
Highlights
Hyperuricemia (HUA) has gradually become a public health burden due to its widespread prevalence and clinical implications
triglyceride-glucose index (TyG) had the highest heart rate (HR) for HUA [1.440, p < 0.001] in men; this was followed by TyG-body mass index (BMI) [1.271, p < 0.001], TyG-WHtR [1.263, p < 0.001], and TyG-waist circumference (WC) [1.259, p < 0.001]
In this large-scale retrospective cohort study, we explored the longitudinal association of TyG with the HUA risk
Summary
Hyperuricemia (HUA) has gradually become a public health burden due to its widespread prevalence and clinical implications. Insulin is the most important hormone that regulates blood glucose levels but has been shown to be an endogenous regulator of urate in the kidney by influencing the actions of some urate transporters [6]. When TyG combines some adiposity indicators such as body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WtHR), its efficiency in evaluating IR may be improved [11, 12]. Identification and intervention of insulin resistance may be beneficial to the prevention of hyperuricemia (HUA) and its related diseases. Us, we conducted this longitudinal study to examine the relation of triglyceride-glucose index (TyG), a simple noninsulin-based IR assessment tool, and its derivatives with the risk of HUA. TyG, body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WtHR) were calculated through anthropometric and biochemical indicators. TyG and its integration with obesity indicators have the potential to help risk stratification and prevention of HUA, especially among women
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
