Abstract
Simple SummaryThe functional SNPs discovered in this work will give helpful information on the crucial molecular markers that may be employed in breeding efforts to improve the heart development of broiler chickens.This study aims to identify molecular marker loci that could be applied in broiler breeding programs. In this study, we used public databases to locate the Transcription factor 21 (TCF21) gene that affected the economically important traits in broilers. Ten single nucleotide polymorphisms were detected in the TCF21 gene by monoclonal sequencing. The polymorphisms of these 10 SNPs in the TCF21 gene were significantly associated (p < 0.05) with multiple growth and body composition traits. Furthermore, the TT genotype of g.-911T>G was identified to significantly increase the heart weight trait without affecting the negative traits, such as abdominal fat and reproduction by multiple methods. Thus, it was speculated that the g.-911T>G identified in the TCF21 gene might be used in marker-assisted selection in the broiler breeding program.
Highlights
Published: 8 February 2022Chicken (Gallus gallus) is the most commonly raised poultry by humans
This study aims to identify the single nucleotide polymorphisms (SNPs) of the Transcription factor 21 (TCF21) gene that are significantly associated with the growth and body composition traits of broilers
The results revealed that the TCF21 gene plays an important role in the adipose, liver, lung, and spleen tissues of broilers (Figure 1)
Summary
Published: 8 February 2022Chicken (Gallus gallus) is the most commonly raised poultry by humans. The growth rate of broilers is positively correlated with these unfavorable traits. It is difficult to simultaneously increase the growth rate and decrease these unfavorable traits in broilers by the traditional phenotypic selection method alone. The combination of molecular genetic marker breeding with traditional phenotypic selection helps to greatly improve the breeding efficiency and accelerate the breeding process [3]. With the rapid development of molecular genetics, genetic markers have been gradually applied in the MAS of livestock and poultry [4]. This technology contributes to substantially improving the breeding efficiency and shortening the generation intervals [5]. SNPs are Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations
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