ASSOCIATIONS OF THE NLR WITH THE RISK OF CARDIOVASCULAR DISEASE IN PATIENTS WITH PRIMARY ALDOSTERONISM

Abstract

Objective: To explore the associations of the NLR with the Risk of Cardiovascular Disease in patients with Primary Aldosteronism Design and method: We conducted a retrospective cohort study enrolling 3039 participants from the People's Hospital of Xinjiang Uygur Autonomous Region. The NLR was computed by dividing the neutrophil count by the lymphocyte count. We assessed the association of NLR with the risk of CVD and CVD subtypes. Results: A total of 3039 patients with a mean age of 49.64±9.16years were included in this study, of which 55% were male.During a median follow-up of 2 years, 217 incident CVD were identified, including 182 incident stroke and 46 incident coronary heart disease (CHD). After adjusting for confounding variables, the higher NLR values(NLR>2.2) was positively associated with the risk of new-onset CVD (hazards ration [HR]: 1.434, 95% confidence interval [CI]: 1.085-1.897, P = 0.014), and new-onset stroke (hazards ration [HR]: 1.533, 95% confidence interval [CI]: 1.137-2.068, P = 0.005),but was not statistically significant with new-onset CHD (hazards ration [HR]: 1.255, 95% confidence interval [CI]: 0.687-2.292, P = 0.277). The RCS curve demonstrated a linear association between the NLR Conclusions: There was a positive association between NLR levels and the risk of CVD in patients with PA. This Finding suggests NLR may be a marker for predicting cardiovascular events in patients with primary aldosteronism