Abstract
The association between the glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism and gynecological cancer susceptibility has been evaluated in many studies. However, the results remain controversial. Thus, this meta-analysis, based on 10 published case-control studies, was designed to clarify the association of the GSTP1 Ile105Val polymorphism with gynecological cancer risk. Our results suggested that there was no significant association between the GSTP1 Ile105Val polymorphism and the risk of gynecological cancer in all genetic models (GG vs. AA: odds ratio [OR] = 1.41, 95% confidence interval [CI] = 0.75-2.26; AG vs. AA: OR = 1.13, 95% CI = 0.74-1.73; AG/GG vs. AA: OR = 1.17, 95% CI = 0.75-1.81; GG vs. AA/AG: OR = 1.38, 95% CI = 0.79-2.42). Similarly, in the subgroup analyses by cancer type, ethnicity, and smoking status, no significant association with any genetic model was observed. In conclusion, the results of our meta-analysis suggest that the GSTP1 Ile105Val polymorphism is not associated with the development of gynecological cancer.
Highlights
Gynecologic malignancies are a major cause of cancer-related death in women worldwide
The Glutathione S-transferases (GSTs) class π enzyme encoded by the glutathione S-transferase P1 (GSTP1) gene is overexpressed in various tumor types and is a major enzyme involved in the inactivation of cigarette smoke carcinogens and other toxic constituents
For the overall study population, our study did not detect a significant association between the GSTP1 Ile105Val polymorphism and gynecological cancer risk in any of the genetic models (GG vs. AA: odds ratios (ORs) = 1.41, 95% confidence intervals (CIs) = 0.75-2.26; AG vs. AA: OR = 1.13, 95% CI = 0.74-1.73; AG/GG vs. AA: OR = 1.17, 95% CI = 0.75-1.81 (Figure 2); GG vs. AA/AG: OR =1.38, 95% CI = 0.79-2.42)
Summary
Gynecologic malignancies are a major cause of cancer-related death in women worldwide. Glutathione S-transferases (GSTs) are a superfamily of phase II enzymes that are expressed in many tissues and are responsible for the metabolism of various xenobiotics and carcinogens by catalyzing the conjugation of glutathione to electrophilic compounds They play a vital role in protecting the cells from oxidative damage and in modulating the induction of other enzymes and proteins in response to DNA damage; they are important for maintaining genomic integrity [2]. GSTs have been widely explored as risk biomarkers for various cancers, including gynecological cancers Among these enzymes, the GST class π enzyme encoded by the GSTP1 gene is overexpressed in various tumor types and is a major enzyme involved in the inactivation of cigarette smoke carcinogens and other toxic constituents. Biochemical studies have indicated that the GSTP1/Val105 variant is 2-3 times less stable than the Ile105 variant [3] and may be associated with the risk of gynecological cancers
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