Associations of steps per day and peak cadence with arterial stiffness in older adults.

Abstract

There is evidence showing an inverse association between steps/day and arterial stiffness in adults. However, the relationship of steps/day and peak cadence with arterial stiffness is poorly understood in older adults. This study aimed to investigate the association between steps/day and peak cadence with arterial stiffness in older adults. This cross-sectional study included 222 community-dwelling older adults (66±5years; 81.5% females; 70.3% with hypertension). Arterial stiffness was measured by aortic pulse wave velocity (aPWV). Steps/day and peak cadence were assessed by accelerometry. The participants were categorized according to the number of steps/day: sedentary <5000; low active 5000-7499; active 7500-9999; highly active 10,000+. Peak cadence was defined as the average of steps/day of the highest 30min (not necessarily consecutive) for all valid days. Generalized linear models were used for data analyses. The active (β=-0.34m/s, 95% CI -0.60, -0.08) and highly active (β=-0.51m/s, 95% CI -0.83, -0.20) groups had lower aPWV compared to the sedentary group. No significant difference was found between the low active group and the sedentary group (β=-0.21m/s, 95% CI -0.46, 0.05). Every increment of 1000steps/day was associated with a decrease of 0.05m/s in the aPWV (95% CI -0.08, -0.02). Every increment of 10 steps/min in peak 30-min cadence was associated with a decrease of 0.05m/s in aPWV (95% CI -0.09, -0.01). Our findings show that easy-to-use proxies of the volume (steps/day) and intensity (peak cadence) of ambulatory behavior are inversely associated with arterial stiffness in older adults. The inverse association of steps/day and peak cadence with arterial stiffness is dose-response.