Associations of Specific HLA-C Loci and Sociodemographic Factors with the Prevalence of Type I psoriasis inIraqi patients.

Abstract

Psoriasis is a chronic, autoimmune inflammatory disease of human skin with unknown etiology and for which there is no cure. It is believed to be genetically and immunologically conditioned and has major negative impact on life’s quality.To determine the impact of inheritance of specific HLA-C loci and some sociodemographic factors on the susceptibility to early onset psoriasis (Type I).Current study includes psoriatic group involve 76 patients (type I) and a match apparently healthy group comprise 87 persons as a control. A PCR based method (low resolution sequence specific primer. PCR-SSP) used to detect CW6, CW7 and CW17 genotypes after inform consent. Current study shows that the CW6 and Cw7 allele significantly associated with early onset psoriasis, while cw17 shows no significant association. There is also higher percentage of patient were in urban than rural resident, with no significant association between smoking and type I psoriasis. Both of CW6 and CW7 genotypes increase the risk of early onset psoriasis. While rural residency decreases the chance of getting type I psoriasis. Furthermore, lack of association with smoking cannot mitigate the effect of passive smoking.