Abstract
The aim of this study was to examine the association of serum isoflavones, adiponectin, and insulin levels with ovarian cancer risk. We gathered cases with histologically confirmed epithelial ovarian cancer at Sapporo Medical University Hospital from October 2010 to September 2012. Potential controls were recruited from female inpatients without any history of cancer or diabetes mellitus in different wards of the same hospital over the same period of time. Serum isoflavones, adiponectin, and insulin levels were measured in order to estimate associations with ovarian cancer risk in a case-control study. Data from 71 cases and 80 controls were analyzed with a logistic regression model adjusting for known risk factors. A significant reduction in ovarian cancer risk was observed for the high tertile of serum daidzein level versus the low (Ptrend<0.001). A significant reduction in ovarian cancer risk was also observed for the high tertile of serum glycitein level versus the low (Ptrend=0.005). Furthermore, a significant reduction in ovarian cancer risk was observed for the high tertile of serum adiponectin level versus the low (Ptrend=0.004). Conversely, serum insulin level showed significantly elevated risk for ovarian cancer with the high tertile versus the low Ptrend<0.001). Decreased serum isoflavones levels, such as those for daidzein and glycitein, decreased serum adiponectin levels, and increased serum insulin levels could be shown to be associated with elevated risk of ovarian cancer.
Highlights
Ovarian cancer is the most frequent cause of death among gynecologic cancers (Parkin et al, 2005)
Decreased serum isoflavones levels, such as those for daidzein and glycitein, decreased serum adiponectin levels, and increased serum insulin levels could be shown to be associated with elevated risk of ovarian cancer
Consistent with previous studies showing the preventive effect of isoflavones against ovarian cancer (Lee et al, 2014; Rossi et al, 2008; Chang et al, 2007; Zhang et al, 2004), our study has indicated that low serum daidzein and glycitein levels were associated with increased risk for ovarian cancer
Summary
Ovarian cancer is the most frequent cause of death among gynecologic cancers (Parkin et al, 2005). The aim of this study was to examine the association of serum isoflavones, adiponectin, and insulin levels with ovarian cancer risk. Adiponectin, and insulin levels were measured in order to estimate associations with ovarian cancer risk in a case-control study. Results: A significant reduction in ovarian cancer risk was observed for the high tertile of serum daidzein level versus the low (Ptrend
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