Abstract
To investigate the associations of sedentary time, physical activity, and cardiorespiratory fitness with skeletal muscle glucose uptake (GU). Sedentary time and physical activity were measured with accelerometers, and VO2 max with cycle ergometry in 44 sedentary adults with metabolic syndrome. Thigh muscle GU was determined with [18 F]FDG-PET imaging. Sedentary time (β=-0.374), standing (β =0.376), steps (β =0.351), and VO2 max (β =0.598) were associated with muscle GU when adjusted for sex, age and accelerometer wear time. Adjustment for body fat-% turned all associations non-significant. Body composition is a more important determinant of muscle GU in this population than sedentary time, physical activity, or fitness.
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