Abstract
ObjectiveTo quantitatively evaluate associations between exposure to triclosan during pregnancy and maternal thyroid hormone levels.MethodThe databases of PubMed, Embase, Web of Science and Cochrane Library were systematically searched to identify relevant studies on the relationship between prenatal exposure to triclosan and maternal levels of serum thyroid hormone published before October 22, 2019. Stata 12.0 was used to examine the heterogeneity among the eligible studies.ResultsSeven studies involving a total of 4,136 participants were included. Overall, descriptive analysis provided no indication that exposure to TCS during pregnancy was related to either maternal FT4 levels (ES = 0.01, 95% CI: −0.03 to 0.05, P = 0.00) or TSH levels (ES = −0.03, 95% CI: −0.13 to 0.07, P = 0.412). Although the results were statistically insignificant, with the increase of urine TCS concentration, maternal FT4 levels exhibited a tendency to increase while TSH levels had a tendency to decrease during pregnancy.ConclusionThe results indicated that exposure to triclosan during pregnancy has no significant influence on maternal levels of thyroid hormone. On account of the inconsistency of existing research designs and study locations, further studies and replication are necessary to confirm these findings.
Highlights
Triclosan (TCS) is one of synthetic antibacterial chemical, which used widely in daily toiletries
We systematically evaluated the relationship between prenatal exposure to TCS and maternal FT4 as well as TSH, in order to elucidate the association between TCS and maternal thyroid hormone levels and provide epidemiological evidence for reducing the incidence of thyroid disease during pregnancy
We performed subgroup analysis to reduce the significant heterogeneity in our study, which can mainly be attributed to differences in calibration methods of urinary TCS concentrations, control of potential confounders, and timing of TCS concentration and thyroid hormone measurements
Summary
Triclosan (TCS) is one of synthetic antibacterial chemical, which used widely in daily toiletries. About 96% of TCS is disposed of down residential drains [1]. TCS has proliferated widely in the ecological environment, eventually reaching humans through. Since TCS might be absorbed by skin and oral mucosa of human it can be found in various human tissues and fluids [6]. It is mainly excreted in the urine, and some researches show that almost all urine samples contain TCS [7,8,9]
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