Associations of Polymorphisms in mir-196a2, mir-146a and mir-149 with Colorectal Cancer Risk: A Meta-Analysis.

Abstract

MicroRNAs (miRNAs) are non-coding RNAs which act as tumor suppressors or oncogenes. And single nucleotide polymorphism (SNP) in miRNA regions is one type of genetic variations in human genome. Various studies have investigated the associations of miRNAs SNP and kinds of cancers. In this article, we searched eligible studies to explore the relationships between mir-196a2 /mir-146a /mir-149 polymorphisms and colorectal cancer (CRC). A literature search of PubMed, Web of Science and ScienceDirect was conducted to identify all relevant studies. Three genetic models with pooled ratio and 95% confidence interval were used to evaluate the associations. We found that mir-196a2 polymorphism was significantly associated with CRC in Asian group (additive model: OR = 1.197, 95%CI 1.084 ~ 1.32, P < 0.001; dominant model: OR = 1.247, 95%CI 1.065 ~ 1.46, P = 0.006; recessive model: OR = 1.298, 95%CI 1.101 ~ 1.531, P = 0.002). And no associations were observed between SNPs of mir-146a, mir-149 and CRC in three genetic models. We also found CRC risk was not associated with mir-146a and mir-149 polymorphisms in population subgroup analysis. The current meta-analysis suggests that mir-196a2 polymorphism is associated with CRC, especially in Asian group. While, no associations have been found between mir-146a /mir-149 polymorphisms and CRC.