Abstract
e12023 Background: Improper work of enzymes involved in the metabolism of reactive oxygen derivatives and detoxification enzymes potentially increase the risk of cancer cell appearance. Polymorphic variants of antioxidant enzymes genes attenuate or stimulate this process by directly modulating the content and quality of protein products of these genes. Hence, their genetic polymorphism can be a risk factor for oncological diseases. We examined the russian residents of the Altai Region in order to clear out the impact of single nucleotide substitutions in the MnSOD (rs4880), GPX1 (rs1050450), GSTP1 (rs1695) genes and deletions in the GSTM1 and GSTT1 genes on the risk of sporadic and familiar BC. Methods: The group consisted of 960 Caucasian women with BC aged 20-79 years (288-familial BC, 672 – sporadic BC), control group consisted of 480 Caucasian women aged 19-84 years without a history of cancer. Genotyping was carried out by real-time PCR using competitive Taq-Man probes (MnSOD, GPX1, GSTP1) or with al...
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