Abstract
Background. The association between plasma omega-6 fatty acids and cardiovascular disease (CVD) is unclear, and discrepancy remains concerning the cardiovascular benefit of the omega-3 fatty acid alpha-linolenic acid. Methods. Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alpha-linolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Results. Results of multivariate analysis showed no statistically significant associations of plasma omega-6 or omega-3 levels with cardiac magnetic resonance imaging measures. Stratification by gender revealed a positive association between DHA and LV mass in women (β = 1.89, P = 0.02; P interaction = 0.003) and a trend for a positive association between DHA and ejection fraction in men (β = 0.009, P = 0.05; P interaction = 0.03). Conclusion. Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men.
Highlights
Contemporary work suggests that consumption of polyunsaturated fatty acids (PUFAs), in place of saturated fats, decreases the risk of cardiovascular disease (CVD) [1]
More accurate objective measures assessing the relationship of PUFAs and left ventricular (LV) mass as well as LV mass/volume ratio in human subjects are lacking
The purpose of this study is to determine the associations between plasma phospholipid omega-6 PUFAs Journal of Nutrition and Metabolism (arachidonic acid (AA) and linoleic acid (LA)) and plasma phospholipid omega-3 PUFAs (EPA, DHA, and ALA) with cardiac magnetic resonance (CMR) measures of cardiovascular structure and function, including aortic distensibility, LV mass, LV mass/volume ratio, ejection fraction, and stroke volume
Summary
Contemporary work suggests that consumption of polyunsaturated fatty acids (PUFAs), in place of saturated fats, decreases the risk of cardiovascular disease (CVD) [1]. Dietary long-chain omega-3 PUFAs (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both found in fatty fish) have been associated with measurable improvements in cardiac hemodynamics and function as assessed by echocardiography. The purpose of this study is to determine the associations between plasma phospholipid omega-6 PUFAs. Journal of Nutrition and Metabolism (arachidonic acid (AA) and linoleic acid (LA)) and plasma phospholipid omega-3 PUFAs (EPA, DHA, and ALA) with cardiac magnetic resonance (CMR) measures of cardiovascular structure and function, including aortic distensibility, LV mass, LV mass/volume ratio, ejection fraction, and stroke volume. Associations of plasma phospholipid fatty acid levels (arachidonic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid (DHA), and alphalinolenic acid) with cardiac magnetic resonance imaging measures of left ventricular (LV) mass, LV volume, ejection fraction, stroke volume, and aortic distensibility were investigated in 1,274 adults. Additional research is warranted to clarify the effects of plasma DHA on cardiac structure and function in women versus men
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