Associations of maternal, perinatal and postnatal factors with the eruption timing of the first primary tooth

Huaying Wu,Kaipeng Xie,Ting Chen,Xiangqin Xu,Yaming Chen,Qian Ma

doi:10.1038/s41598-019-39572-w

Huaying Wu, Kaipeng Xie + Show 4 more

Open Access

https://doi.org/10.1038/s41598-019-39572-w

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Abstract

We recruited 1296 mothers in their first trimester from the Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University between May 2014 and September 2015 to investigate the associations of maternal, perinatal and postnatal factors with the eruption timing of the first primary tooth (ETFPT) in a Chinese population. We collected maternal demographic information and clinical data during the perinatal and postnatal period, and oral examinations of the infants were performed by a doctor at 6, 9 and 12 months of age. Multiple regression analysis was used to identify significant explanatory variables for ETFPT. The mean age at eruption of the first primary tooth for all the infants was 6.82 ± 1.90 months. After adjustment for confounders, higher maternal childbearing age (β = 0.57; 95%CI = 0.13–1.02), female sex (β = 0.26; 95%CI = 0.07–0.52), and low birth weight (β = 0.98; 95%CI = 0.20–1.76) were significantly associated with delayed eruption of the first primary tooth, while macrosomia (β = −0.79; 95%CI = −1.30–−0.28) was significantly associated with earlier eruption of the first primary tooth. Maternal childbearing age, infant sex and infant birth weight were significant determinants of ETFPT.

Highlights

The formation and development of human primary teeth begins at the end of the fifth week of gestation[1]
Mothers of higher maternal childbearing age (β = 0.57, 95%CI = 0.13–1.02, p = 0.010), female infants (β = 0.26, 95%CI = 0.07–0.52, p = 0.022), and low infant birth weight (β = 0.98, 95%CI = 0.20–1.76, p = 0.010) were significantly associated with delayed eruption timing of the first primary tooth (ETFPT), while macrosomia (β = −0.79, 95%CI = −1.30–−0.28, p = 0.000) was significantly associated with earlier ETFPT (Table 2)
We found that higher maternal childbearing age and low birth weight were significantly associated with delayed ETFPT, while macrosomia was significantly associated with earlier ETFPT

Summary

Introduction

The formation and development of human primary teeth begins at the end of the fifth week of gestation[1]. The GUSTO cohort study in Singapore[24] found that infant weight gain from birth to 3 months, ethnicity and maternal childbearing age were associated with the timing of the eruption of the first tooth. A study from the Southampton Women’s Survey[25] found that maternal smoking and socioeconomic status were associated with tooth eruption. Taken together, these cohort studies[23,24,25] were based on relatively large populations and focused on comprehensive data, including maternal, perinatal and postnatal data; in contrast, their results are not entirely consistent. Our study aimed to evaluate the relationships between maternal, perinatal and postnatal factors and ETFPT of infants in a large cohort of Chinese mothers in Nanjing, China

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Discussion

Conclusion