Abstract
Lymphotoxin-a (LTA) may be associated with the pathogenesis of inflammatory diseases. To assess the association of the LTA rs909253 A/G polymorphism with plasma level and risk of ankylosing spondylitis (AS) in a Chinese Han population. Genotyping and LTA plasma were tested by mass spectroscopy and enzyme-linked immunosorbent assay (ELISA), respectively. The results showed that the average plasma level of LTA in AS was significantly lower than in the controls (P = 0.000). Our results also indicated that LTA rs909253 A/G was associated with a decreased risk of AS (G vs. A: P = 0.014). Significant differences were also found between the rs909253 A/G genotype and down-regulated plasma level in AS patients, compared with controls. After stratification analysis, a decreased risk of AS was associated with the LTA rs909253 G allele (G vs. A) among female patients, younger patients (Yr. < 30), HLA-B27-positive patients. In addition, In conclusion, LTA rs909253 A/G genotype has a significant relationship with decreased susceptibility to AS.
Highlights
Ankylosing spondylitis (AS) is a common rheumatic chronic inflammatory disease
The observed genotype frequencies for the polymorphism in controls were in Hardy–Weinberg equilibrium (HWE) for LTA rs909253 A/G (P = 0.109)
A decreased risk of ankylosing spondylitis (AS) was associated with the LTA rs909253 G allele (G vs. A) among female patients (OR = 0.55, 95%confidence intervals (CIs) = 0.31– 0.97, P = 0.040), younger patients (Yr. < 30) (OR = 0.56, 95%CI = 0.35–0.89, P = 0.014), HLA-B27-positive patients (OR = 0.73, 95%CI = 0.54–0.99, P = 0.040)
Summary
Ankylosing spondylitis (AS) is a common rheumatic chronic inflammatory disease. It often occurs in young men. A study by Fabiano Aparecido de Medeiros et al explored the association between the LTA rs909253 polymorphism with plasma LTA level, the susceptibility for RA, and the presence of autoantibodies. Interaction between the presence of autoantibodies and B1 allele has significantly related to the increase of plasma LTA level in RA patients[17]. Production of LTA in AS Patients, Controls and Different Genotypes.
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