Abstract
AimsTo investigate the associations of dyslipidemia with insulin resistance and β cell function in individuals with normal glucose tolerance (NGT) and different categories of impaired glucose regulation (IGR).Methods544 subjects (365 with dyslipidemia and/or IGR and 179 with normal lipid and glucose tolerance) were enrolled in the study. All subjects underwent oral glucose tolerance test (OGTT). HOMA-IR was used to evaluate insulin sensitivity. Disposition index (DI) was used to evaluate β cell function. Multiple linear regression analysis was performed to assess correlations among lipid profiles, insulin resistance and β cell function.ResultsAmong subjects with NGT, those with dyslipidemia had higher level of HOMA-IR but lower level of DI. While among subjects with different categories of IGR, those with dyslipidemia and CGI had significantly decreased DI. No obvious differences of insulin resistance or β cell function were found in IFG or IGT subjects with or without dyslipidemia. TG and HDL-C were correlated with HOMA-IR (β = 0.79, p <0.001; β = -0.38, p = 0.027, respectively, compared with subjects in the low level groups). Moreover, TG and TC were negatively correlated with DI (β = -2.17, p = 0.013; β = -2.01, p = 0.034 respectively, compared with subjects in the low level groups) after adjusting for confounding parameters.ConclusionsDyslipidemia induces insulin resistance and impaired β cell response to insulin resistance in individuals with NGT. Furthermore, dyslipidemia diminishes β cell function in subjects with CGI. TG and HDL-C were correlated with insulin resistance, and TG, TC were negatively correlated with β cell response to insulin resistance in non-diabetic individuals.
Highlights
Type 2 diabetes mellitus (T2DM), as one of the most common chronic diseases, causes serious morbidity and mortality and imposes a heavy economic burden in the world [1]
No obvious differences of insulin resistance or β cell function were found in impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) subjects with or without dyslipidemia
The results revealed that after adjusting for confounding factors, TG and high density lipoproteincholesterol (HDL-C) were correlated with homeostasis model assessment for insulin resistance (HOMA-IR) [For TG, adjusted β of high level group was 0.79 (0.52, 1.06), p
Summary
Type 2 diabetes mellitus (T2DM), as one of the most common chronic diseases, causes serious morbidity and mortality and imposes a heavy economic burden in the world [1]. In order to answer this question, we should investigate the role of dyslipidemia in β cells function in an early stage, namely non-diabetic subjects. Previous studies have demonstrated the phenomenon that impaired pancreatic β cells function caused by dyslipidemia precedes the manifestation of T2DM [3,4,5,6,7]. Few studies have clearly clarified the effects of dyslipidemia on insulin resistance and β cell function in subjects with NGT and different categories of IGR, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and combined glucose intolerance (CGI). The associations of different lipid indices with insulin resistance and β cell function need further investigation in those non-diabetic individuals, which could provide more evidence of the utilization of these lipid indices as potential clinical tools for screening of high-risk individuals
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