Associations of hypoxia inducible factor-1α gene polymorphisms with susceptibility to digestive tract cancers: a case–control study and meta-analysis

Abstract

We aim to investigate the correlations of hypoxia inducible factor-1α (HIF-1α) C1772T (rs11549465) and G1790A (rs11549467) gene polymorphisms with digestive tract cancers. A sum of 267 digestive tract cancers patients were hospitalized in Taizhou Central Hospital of Zhejiang Province as case group between December 2012 and December 2014. Additionally, 275 healthy people who had a physical examination in our hospital at the same time were selected as control group. Polymerase chain reaction-restriction fragment length polymorphism was utilized for detecting allele and genotype frequency of different locus in case and control group. Meta-analysis was performed using Comprehensive Meta-analysis 2.0 (Biostat Inc., Englewood, New Jersey, USA). Our result showed statistical significance only exists in family history of cancer between case and control group (P < 0.05). Both C1772T (rs11549465) and G1790A (rs11549467) polymorphisms showed positive correlations with an increasing risk of digestive tract cancers. The frequencies of TT genotype of C1772T (rs11549465) and GA, AA genotypes of G1790A (rs11549467) polymorphisms in case group were evidently higher compared with the controls (all P < 0.05). Besides, the comparison of allele and dominant models of HIF-1α C1772T (rs11549465) and G1790A (rs11549467) between two groups showed a significant difference (all P < 0.05). Meta-analysis results further confirmed that the onset risk of digestive tract cancers may be improved under allele and dominant models of HIF-1α C1772T (rs11549465) and G1790A (rs11549467) (all P < 0.05). Single nucleotide polymorphisms of HIF-1α C1772T (rs11549465) and G1790A (rs11549467) may play a role in development of digestive tract cancers.