Abstract
Associations of history of vaccination and hospitalization due to infection with risk of monoclonal B-cell lymphocytosis
Highlights
Prior studies have suggested that common infections are associated with subsequent increased risk of chronic lymphocytic leukemia (CLL) [6, 7]
Study participants were from the Mayo Clinic Biobank, a large-scale bio-repository of adult patients recruited through mailed invitation prior to their visit in primary care-based clinics, which ascertains patients’ vaccination history regardless of when vaccinations were given [14]
Participants had stored peripheral blood mononuclear cells (PBMC) collected from 7/14/2009 to 12/31/2020 that were screened for Monoclonal B-cell lymphocytosis (MBL), were residents of Olmsted county, Minnesota at the time of sample collection, were 40 years of age or older with no prior history of hematologic malignancy, and had at least five years of medical history in the community prior to screening
Summary
Prior studies have suggested that common infections (e.g., pneumonia, herpes zoster, sinusitis) are associated with subsequent increased risk of CLL [6, 7]. Individuals with MBL have an increased risk of subsequent infections [4, 5], and some studies have suggested the clonal B-cell population may directly alter immune function [10]. It is currently unknown whether infection prior to developing CLL is due to infections being an inciting event to CLL, or if infections are strictly a consequence of having MBL. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) to evaluate the association of prior vaccinations and serious infections with MBL risk (overall and by low-count CLL-like), adjusting for age (continuous) at sample collection, sex, and race/ethnicity. Received: 2 July 2021 Revised: 13 January 2022 Accepted: 26 January 2022 Published online: 15 February 2022
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