Abstract
Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies
Highlights
ObjectivesOur goal was to definitively assess the evidence for heterogeneity in associations between nongenetic risk factors and breast cancer subtypes defined by marker expression in tumors
Previous studies have suggested that breast cancer risk factors are associated with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors
Case–control analyses showed that nulliparity, increasing age at first birth, and obesity in younger women showed the expected associations with the risk of ER1 or PR1 tumors but not triple-negative or core basal phenotype (CBP) tumors
Summary
Our goal was to definitively assess the evidence for heterogeneity in associations between nongenetic risk factors and breast cancer subtypes defined by marker expression in tumors
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