Abstract

Abstract Recently, an increasing amount of data on the connection between neuro-endocrine and immune systems has been gathered. Results of molecular genetic research have provided evidence for a common language of these systems including neurotransmitters, hormones and cytokines. It has been proved that the immune system is capable of producing neurotransmitters and hormones and even the endocrine system can prepare cytokines. This integrative (holistic) approach makes possible the investigation of physiological and pathological events as interactions of psychoneuro-endocrine-immune systems. The associations of autoimmune diseases and the autoimmune polyendocrine syndromes constitute a heterogeneous group of disorders characterised by decreased or lost immune tolerance against self-antigens. Molecular genetic research has explored the mechanism of the associations of diseases that are called organ-specific. Autoimmune polyendocrine syndrome type 1 is characterised by the presence of at least two of the th...

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