Associations between XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and ovarian cancer.

Wei Zhang,Zhifen Zhang

doi:10.18632/oncotarget.13361

Abstract

Recent studies explored XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and ovarian cancer (OC) risk. However, the association between these two single nucleotide polymorphisms and OC risk remains conflicting. Thus, we conducted a comprehensive systematic review and meta-analysis to investigate the association. We searched the databases of PubMed, and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. 15 case-control studies published in 11 papers including 4,757 cases and 8,431 controls were included in this meta-analysis. No associations were obtained between XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and OC risk. Stratification analyses of Hardy–Weinberg equilibrium status indicated that rs3218536 polymorphism was associated with the decreased risk of OC when in analysis of combined HWE positive studies. In conclusion, this meta-analysis indicates that XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms may not be associated with the risk of OC.

Highlights

Ovarian cancer (OC), leading cause of gynaecologic cancer death, is the second most common gynaecologic cancer [1]
After screening the titles and abstracts, 36 citations were excluded. 27 citations were selected for further full text review. 16 citations were excluded: 6 were meta-analyses [19,20,21,22,23,24]; 6 not case-control studies [25,26,27,28,29,30]; 3 investigated other polymorphisms [14, 31, 32]; 1 did not provide detailed genotyping data [33]
DNA repair systems are important for protecting against mutations and are necessary for maintaining the integrity of the genome

Summary

Introduction

Ovarian cancer (OC), leading cause of gynaecologic cancer death, is the second most common gynaecologic cancer [1]. OC is mainly classified into four subtypes: serous, endometrioid, mucinous, and clear cell. Most of malignant OCs are of epithelial origin [2]. The pathogenesis of OC still remains unclear. Family history of OC, gravidity, genetic and other environmental factors might be account for the etiology of OC [3, 4]. The known ovarian cancer susceptibility genes explain nearly 40% of the excess familial risk of OC [5]

Methods

Results

Conclusion