Associations Between XRCC1 Arg399Gln, Arg194Trp, and Arg280His Polymorphisms and Risk of Differentiated Thyroid Carcinoma: A Meta-analysis

Yang Du,Dian-Jun Sun,Dan-Dan Li,Li-Yuan Han,Yan-Hui Gao,Hui Liu

doi:10.7314/apjcp.2013.14.9.5483

Abstract

Associations between Arg399Gln, Arg194Trp and Arg280His polymorphisms of the XRCC1 gene and risk of differentiated thyroid carcinoma (DTC) have been widely studied but the findings are contradictory. We performed a meta-analysis in the present study using STATA 11.0 software to clarify any associations. Electronic literature databases and reference lists of relevant articles revealed a total of 10, 6 and 6 published studies for the Arg399Gln, Arg194Trp and Arg280His polymorphisms, respectively. No significant associations were observed between Arg399Gln and DTC risk in all genetic models within the overall and subgroup meta-analyses, while the Trp/Trp vs Arg/Arg and recessive model of the Arg194Trp polymorphism was associated with DTC susceptibility, and the dominant model of Arg280His polymorphism contributed to DTC susceptibility in Caucasians. Our meta-analysis suggests that XRCC1 Arg194Trp may be a risk factor for DTC development.

Highlights

The majority of endocrine malignancies are thyroid cancer (TC), which accounts for more than 90% and contributes to more than 50% of all deaths from endocrine cancers (Gilfillan 2010; Aschebrook-Kilfoy et al, 2011)
No significant associations were observed between Arg399Gln and differentiated thyroid carcinoma (DTC) risk in all genetic models within the overall and subgroup meta-analyses, while the Trp/Trp vs Arg/Arg and recessive model of the Arg194Trp polymorphism was associated with DTC susceptibility, and the dominant model of Arg280His polymorphism contributed to DTC susceptibility in Caucasians
A significant association was found between the Trp/Trp vs Arg/Arg, recessive model and DTC susceptibility after excluding one study in the Arg194Trp meta-analysis (Ryu et al, 2011), because it showed a significant effect of gender between cases and controls even though the higher incidence of DTC among women than men is already well-known (Parkin et al, 2005), the corresponding odds ratio (OR) and 95%confidence interval (CI) were 1.87 (1.20–2.90) and 1.79 (1.17–2.74), respectively (Table 2)

Summary

Introduction

The majority of endocrine malignancies are thyroid cancer (TC), which accounts for more than 90% and contributes to more than 50% of all deaths from endocrine cancers (Gilfillan 2010; Aschebrook-Kilfoy et al, 2011). Most TC patients do not have a history of radiation exposure, and studies reported that gene polymorphisms including DNA repair genes influence on thyroid cancer susceptibility (Gudmundsson et al, 2012; Endrzejewski et al, 2012), genetic variations in DNA repair genes are thought to modify DNA repair capacity and related to cancer risk (Alberg et al, 2013), indicating that potential predisposing genetic factors may modify an individual’s susceptibility to TC. Associations between Arg399Gln, Arg194Trp and Arg280His polymorphisms of the XRCC1 gene and risk of differentiated thyroid carcinoma (DTC) have been widely studied but the findings are contradictory. Conclusions: Our meta-analysis suggests that XRCC1 Arg194Trp may be a risk factor for DTC development

Methods

Results

Conclusion