Abstract
Aim: This work was designed to investigate the associations between vitamin D metabolites, VDR gene polymorphismsand echocardiographic markers in a population of patients with cardiovascular disease. Methods: Echocardiographic markers for 42 patients were determined with tissue Doppler techniques. PCR-restriction fragment length polymorphismanalysisidentified genetic variants ApaI, TaqI, BsmI and FokI. A validated UHPLC-MS/MS methoddetermined vitamin D metabolites. Results: Patients with the ApaI-GT genotype exhibited a lower pressure gradient across the aortic valve than ApaI-TT carriers. BMI, ApaI-GT, TaqI-TC, aortic arch diameterand maximal pressure gradient were significant univariate predictors of hypertension. Conclusion: A potential link existsbetween VDR gene polymorphisms and cardiovascular function.
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