Abstract
BackgroundRecent studies have reported the associations between vitamin D receptor (VDR) polymorphisms and colorectal cancer (CRC), but the results were not always consistent. This meta-analysis aims to evaluate whether VDR polymorphisms are associated with CRC susceptibility.Materials And MethodsStudies on the associations between VDR polymorphisms and CRC were retrieved from the Web of Science, PubMed, the Chinese Biomedical Database (CBM), Chinese National Knowledge Infrastructure (CNKI) and Wanfang (Chinese) databases. The odds ratio (OR) with 95% confidence intervals (CIs) was obtained.ResultsThirty-nine articles met all inclusion criteria and were included in the meta-analysis including 22101 CRC cases and 23696 healthy controls. The 39 articles consisted of five VDR gene polymorphisms including ApaI, FokI, BsmI, TaqI and Cdx2. The results of meta-analysis showed that the FokI polymorphism was on the fringe of statistically significant in the comparisons of F allele vs. f allele in fixed model (OR = 1.029, 95% CI = 0.999–1.059, Praw = 0.057, PFDR = 0.057). Moreover, for the associations between BsmI polymorphism with CRC, We observed significant differences in allele frequencies, the homozygous model and the dominant model between CRC patients and healthy controls (B vs. b: OR = 0.862, 95% CI = 0.761–0.976, Praw = 0.019, PFDR = 0.019; BB vs. bb: OR = 0.786, 95% CI = 0.636–0.972, Praw = 0.026, PFDR = 0.039; BB + Bb vs. bb: OR = 0.934, 95% CI = 0.888-0.982, Praw = 0.008, PFDR = 0.024, respectively).ConclusionsThis meta-analysis suggests that BsmI is associated with CRC risk and FokI might be a risk factor for CRC. However, these associations with CRC need further studied.
Highlights
Colorectal cancer (CRC) is a major health problem and is currently ranked third for both cancer incidence and mortality [1]
The 39 articles consisted of five vitamin D receptor (VDR) gene polymorphisms including ApaI, FokI, BsmI, TaqI and Cdx2
The results of meta-analysis showed that the FokI polymorphism was on the fringe of statistically significant in the comparisons of F allele vs. f allele in fixed model (OR = 1.029, 95% confidence intervals (CIs) = 0.999–1.059, Praw = 0.057, PFDR = 0.057)
Summary
Colorectal cancer (CRC) is a major health problem and is currently ranked third for both cancer incidence and mortality [1]. In spite of the revised treatment patterns, CRC remains a major cause of cancer mortality. The incidence rate of CRC has been increasing greatly in China in the past few years, which accounts for about 6.5% of total cancers in urban areas and 4.6% in rural areas [3]. Recent studies have reported the associations between vitamin D receptor (VDR) polymorphisms and colorectal cancer (CRC), but the results were not always consistent. This meta-analysis aims to evaluate whether VDR polymorphisms are associated with CRC susceptibility
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