Associations between the rs6010620 polymorphism in RTEL1 and risk of glioma: a meta-analysis of 20,711 participants.

Yao Wu,Kai Zhou,Xiang Tong,Shu Jiang,Ling-Li Tang,Chuan-Hong Zhong

doi:10.7314/apjcp.2014.15.17.7163

Abstract

Associations between the rs6010620 polymorphism in the regulator of telomere elongation helicase1 (RTEL1) gene and glioma have been widely reported but the results were not inconclusive. The aim of the current study was to investigate the association between the rs6010620 polymorphism in RTEL1 gene and risk of glioma by meta-analysis. We searched PubMed, Embase, Wanfang Weipu and CNKI (China National Knowledge Infrastructure) databases, which included all research published 05 May 2014. A total of 8,292 cases and 12,419 controls from 14 case-control studies involving the rs6010620 polymorphism in the RTEL1 gene were included. Statistical analysis was performed using STATA 12.0 software. The results indicated that the rs6010620 polymorphism in RTEL1 gene was indeed associated with risk of glioma (OR=1.474, 95%CI=1.282-1.694, p<0.001). On subgroup analysis by ethnicity, we found associations between the rs6010620 polymorphism in the RTEL1 gene and risk of glioma in both Caucasians and Asians. The current meta-analysis suggested that the rs6010620 polymorphism in the RTEL1 gene might increase risk of glioma. In future, larger case-control studies are needed to confirm our results.

Highlights

Glioma are the most common adults tumors of the central nervous system (CNS), accounting for a majority (80%) of glioblastoma (Dolecek et al, 2012; Walsh et al, 2013)
The aim of the current study was to investigate the association between the rs6010620 polymorphism in regulator of telomere elongation helicase1 (RTEL1) gene and risk of glioma by meta-analysis
The results indicated that the rs6010620 polymorphism in RTEL1 gene was associated with risk of glioma (OR=1.474, 95%confidence intervals (CI)=1.282-1.694, p

Summary

Introduction

Glioma are the most common adults tumors of the central nervous system (CNS), accounting for a majority (80%) of glioblastoma (Dolecek et al, 2012; Walsh et al, 2013). Previous large number of studies revealed that several candidate risk genetic variants of genes may associate with glioma, including 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) ( Shete et al, 2009; Schoemaker et al, 2010; Safaeian et al, 2013). Other studies indicated that the rs6010620 polymorphism in regulator of telomere elongation helicase (RTEL1) gene was associated with the risk of glioma (Chen et al, 2011; Li et al, 2013a; Walsh et al, 2013). Associations between the rs6010620 polymorphism in the regulator of telomere elongation helicase (RTEL1) gene and glioma have been widely reported but the results were not inconclusive. The aim of the current study was to investigate the association between the rs6010620 polymorphism in RTEL1 gene and risk of glioma by meta-analysis. Conclusions: The current meta-analysis suggested that the rs6010620 polymorphism in the RTEL1 gene might increase risk of glioma. Larger case-control studies are needed to confirm our results

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Results