Abstract
BackgroundViral attachment and cell entry host factors are important for viral replication, pathogenesis, and the generation and sustenance of immune responses after infection and/or vaccination, and are plausible genetic regulators of vaccine-induced immunity.MethodsUsing a tag-SNP approach in candidate gene study, we assessed the role of selected cell surface receptor genes, attachment factor-related genes, along with other immune genes in the genetic control of immune response variations after live rubella vaccination in two independent study cohorts.ResultsOur analysis revealed evidence for multiple associations between genetic variants in the PVR, PVRL2, CD209/DC-SIGN, RARB, MOG, IL6 and other immune function-related genes and rubella-specific neutralizing antibodies after vaccination (meta p-value <0.05).ConclusionOur results indicate that multiple SNPs from genes involved in cell adhesion, viral attachment, and viral entry, as well as others in genes involved in signaling and/or immune response regulation, play a role in modulating humoral immune responses following live rubella vaccination.
Highlights
Host genetic determinants play an important role in the generation and regulation of humoral and cellular immune responses after vaccination and/or infection [1,2]
Recent discoveries point to the role of newly discovered cellular receptors and attachment factors for several important human viruses, including rubella virus (Myelin Oligodendrocyte Glycoprotein, myelin oligodendrocyte glycoprotein (MOG)), measles virus, Rift Valley Fever virus/rift valley fever virus (RVFV) (DC-SIGN/CD209), poliovirus (Poliovirus receptor, PVR/CD155, Nectin-5) and herpesvirus in infection, disease pathogenesis and immunity [11,12,13,14,15,16,17,18,19,20]
Distinct Cohorts We found three replicated genetic associations between SNPs tagging the poliovirus receptor gene (PVR, nectin-like protein 5, CD155) in high linkage disequilibrium/LD, and rubella-specific neutralizing antibodies
Summary
Host genetic determinants play an important role in the generation and regulation of humoral and cellular immune responses after vaccination and/or infection [1,2]. Cell entry, fusion with the cell membrane, and viral genome translocation into target cells are essential early stages initiating the viral infectious cycle. These are key steps in viral replication and dissemination, as well as virus-host interactions involving the generation and maintenance of the immune response. Viral attachment and cell entry host factors are important for viral replication, pathogenesis, and the generation and sustenance of immune responses after infection and/or vaccination, and are plausible genetic regulators of vaccine-induced immunity
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
