Abstract
BackgroundEpidemiological data regarding the association between serum levels of IGF-I and bone mineral acquisition during childhood are scarce. Here, we investigated the association between serum levels of IGF-I and bone status during puberty.MethodsWe analyzed prospective 3-year follow-up data of 254 community-dwelling children who completed both baselines (at age 11.2 years) and follow-up (at age 14.2 years) surveys in Hamamatsu, Japan. Total body (TB) bone area and bone mineral parameters were assessed using dual-energy X-ray absorptiometry.ResultsDuring the 3-year follow-up period, there were significant (P < 0.05) increases in total body less head (TBLH) areal bone mineral density (aBMD), TBLH bone mineral content (BMC), and TB bone area, and a significant decrease in TB bone mineral apparent density (BMAD, volumetric bone mineral density, vBMD). IGF-I levels showed significant positive relationships with TBLH BMC and TBLH aBMD at both baseline and follow-up. TBLH aBMD in boys and TB BMAD in girls at follow-up showed significant increases from the lowest to highest quartiles of baseline IGF-I levels after adjusting for confounding factors. Similarly, changes in TBLH aBMD in boys and TB BMAD in girls during the 3-year follow-up period showed significant increases from the lowest to highest quartiles of baseline IGF-I levels after adjusting for confounding factors.ConclusionsThese results suggest that pubertal children with high levels of serum IGF-I tended to have high bone mineral acquisition later on.
Highlights
Epidemiological data regarding the association between serum levels of insulin-like growth factor-I (IGF-I) and bone mineral acquisition during childhood are scarce
In the present 3-year follow-up study, which had a relatively large sample size (n = 254), we investigated associations between serum levels of IGF-I at age 11 years and bone mineral parameters such as bone area, bone mineral content (BMC, g), areal bone mineral density, and volumetric bone mineral density from age 11 to 14 years
Total body (TB) bone mineral apparent density (BMAD) significantly decreased from baseline to follow-up
Summary
Epidemiological data regarding the association between serum levels of IGF-I and bone mineral acquisition during childhood are scarce. We investigated the association between serum levels of IGF-I and bone status during puberty. Bone mass content increases mainly during the first 3 years of life and during the pubertal growth spurt [2]. A longitudinal study reported that adolescence is clearly a critical time for bone mineralization because 26% of adult calcium is accumulated in the 2 years of Circulating insulin-like growth factor-I (IGF-I) is a mediator of growth hormone and appears to have a direct impact on bone growth. In addition to circulating IGF-I, most tissues express IGF-I locally [5]. Bone growth relies on circulating IGF-I in blood [6], and autocrine/paracrine IGF-I in tissues [7]. Direct evidence for the importance of the autocrine/paracrine role of IGF-I
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