Associations between serum bilirubin levels and essential trace elements status in an adult population.

You-Fan Peng,Ye-Sheng Wei

doi:10.18632/oncotarget.18351

Abstract

ObjectiveThis paper aims to evaluate the relations between serum bilirubin and essential trace elements in an adult population.ResultsDemographic and clinical data were stratified according to the median of serum bilirubin concentrations (50th percentiles). There were statistical differences in regarding with age, body mass index, white blood count, hemoglobin, mean corpuscular hemoglobin, alanine aminotransferase, creatinine, high-sensitivity C-reactive protein, iron, zinc and copper. Studying the correlation of serum bilirubin levels with iron, zinc, copper and high-sensitivity C-reactive protein, we found positive correlations for iron and zinc, and negative correlations for high-sensitivity C-reactive protein and copper in whole participants. Similar results of correlation analysis were repeated when the further analyses were performed separately for subjects with high and low serum bilirubin concentrations. Similar results were also observed in gender-based stratified analysis. Multiple linear regression analysis revealed that serum bilirubin levels were independently correlated with serum iron, zinc and copper.Materials and MethodsThe cross-sectional study involved 264 healthy subjects.ConclusionsThe current study demonstrated that serum bilirubin within the reference range is correlated with iron, zinc and copper in an adult population, regardless of potential confounders.

Highlights

Iron, copper and zinc are essential trace elements in human body [1]
Body mass index, White blood count (WBC), copper and highsensitivity C-reactive protein (hs-C-reactive protein (CRP)) decreased from the low to the high serum bilirubin concentrations
Serum bilirubin and trace elements in multiple linear regression analysis Multiple linear regression analysis revealed that serum bilirubin levels were independently correlated with serum iron, zinc and copper, when gender, age, body mass index, WBC, hemoglobin, mean corpuscular hemoglobin (MCH), ALT, AST, Cr, hs-CRP, iron, zinc and cooper were considered as independent variables, and serum bilirubin were served as dependent variables in multiple linear regression analysis (Table 3)

Summary

Introduction

Copper and zinc are essential trace elements in human body [1]. Previous studies showed that inflammation was a main factor to induce changes in zinc, iron and copper concentrations [2,3]. Low serum levels of iron have been found to be negative correlated with some traditional inflammatory markers such as highsensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF) and adiponectin [4], and inflammatory cytokines can decrease serum iron concentrations with no evidence of iron deficiency [5]. There was an association between serum zinc and inflammation in community population [6]. Serum iron, copper and zinc levels may be associated with low-grade inflammatory conditions in human body [10]

Methods

Results

Conclusion