Associations between polymorphisms of long non-coding RNA MEG3 and risk of colorectal cancer in Chinese.

Xiangming Cao,Lei Xi,Weisheng Shen,Lichun Deng,Youfang Hu,Shulin Zhuang,Huaming Sheng

doi:10.18632/oncotarget.7764

Abstract

Maternally expressed gene 3 (MEG3), a long non-coding RNA (lncRNA), is involved in cancer development and metastasis. The objective of the present study was to evaluate whether common single nucleotide polymorphisms (SNPs) in MEG3 could be related with colorectal cancer risk in Chinese. We genotyped six tagSNPs of MEG3 in a colorectal cancer case-control study including 518 cases and 527 control subjects. Multivariate logistic regression analysis was applied to calculate adjusted odds ratios (ORs). We found that MEG3 rs7158663 AA genotype, but not GA genotype, had significant increased colorectal cancer risk, compared with GG genotype (OR = 1.96 and P = 0.006 for AA versus GG, and OR = 1.20 and P = 0.171 for GA versus GG). Further stratified analysis indicated that the increased risk was significantly correlated with individuals with age ≤ 60 and family history of cancer. However, there was no significant association between rs7158663 and colorectal tumor site and stage (P = 0.842 for tumor site, and P = 0.601 for tumor stage). These results demonstrate that genetic variants in MEG3 may contribute to the development and risk of colorectal cancer. Further studies are required to confirm these findings.

Highlights

Colorectal cancer is the third most commonly diagnosed cancer in the world [1]
Recent studies have demonstrated that long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) is abnormal expressed in various human cancers, such as hepatocellular carcinoma [9, 10], bladder cancer [11], glioma [12], and gastric cancer [13]
We investigated the association of tagging SNPs (tagSNPs) of MEG3 with colorectal cancer risk in a population of Chinese

Summary

Introduction

The incidence and mortality of colorectal cancer in China have been increasing in last two decades [2]. It is well known that colorectal cancer susceptibility is related to multiple environmental factors and genetic alterations, such as genetic mutations or polymorphisms [3, 4]. The role of genetic polymorphism and colorectal cancer susceptibility still remains unknown. Previous studies have indicated that polymorphisms in lncRNAs may influence the risk of gastric cancer [7, 8]. Little is known about the single nucleotide polymorphisms (SNPs) in MEG3 and colorectal cancer risk

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Conclusion