ASSOCIATIONS BETWEEN PATHOGENETIC FACTORS OF METABOLIC AND CIRCULATORY SYNDROMES IN YOUNG ADULTS IN A RUSSIAN ARCTIC CITY

Abstract

Introduction. The presence of pathogenetic factors of metabolic and circulatory syndromes from a young age substantially increases the risk of atherosclerosis later in life. Extreme climatic conditions of the Arctic may also contribute to early onset of atherogenesis and neuroendocrine metabolic disorders. Aim. To study the complex associations between a large set of anthropometric, clinical, laboratory, and genetic factors in young adults in a Russian Arctic city. Methods. In total, 185 young adults participated in a cross-sectional study in a city of Arkhangelsk. Data on180 anthropometric, clinical and laboratory and genetic variables were collected for a comprehensive analysis of their interactions and identification of complex patterns related to proatherogenic conditions. Statistical methods of topological and metric data analysis were applied. Results. Anthropometric and bioimpedance indicators of excess weight were associated with glucose levels, insulin, HOME index, lipid profile (HDL, LDL), vitamin D- and iron deficiencies. Hyperglycemia was associated with lower waist/hip ratio (p = 0.042), higher extracellular water content (p = 0.0283), amount of adipose tissue (p = 0.030), increased uric acid levels (p < 0.001), HOMA index (p < 0.001) and insulin growth factor (p = 0.006) as well as decreased levels of red blood cells (p = 0.016), T4 (p < 0.001) and pyruvate (p = 0.016). Iron deficiency was associated with low levels of red blood cells (p = 0.003), hemoglobin (p < 0.001), elevated levels of creatine kinase (p = 0.028) and parathyroid hormone (p = 0.031), decreased blood antioxidant resource (ImAnOx index, p = 0.034), and decreased blood lactate levels (p = 0.035). Conclusions. Identification of the associations between pathogenetic factors of metabolic and circulatory syndromes in young adults in the Arctic shows the importance of their early detection, prevention and correction at young age with the further going aim reduce the prevalence of cardiovascular diseases in the Arctic. The analysis also suggests the role of vitamin D deficiency in development of metabolic and circulatory syndromes.