Abstract
Objective The endocrine function of bone in energy metabolism may be mediated by the osteocalcin (OC). We examined the association between OC and energy metabolism among Chinese postmenopausal women. Design and Setting. A cross-sectional cohort study enrolling 1635 participants was conducted using data from the Peking Vertebral Fracture study. Partial correlation analysis was performed to explore the correlation of OC, parathyroid hormone (PTH), or 25-hydroxyvitamin D (25(OH)D) with glycemic and lipid metabolic parameters. A logistic regression model was used to investigate the association of OC, PTH, or 25(OH)D with the prevalence of diabetes and dyslipidemia. Results Serum levels of OC, PTH, and 25(OH)D were all positively correlated with serum cholesterol levels, whereas only OC was negatively associated with serum glucose level. In the logistic regression model, both OC and PTH were negatively associated with the prevalence of diabetes (odds ratio [OR], 95% confidence interval [95% CI]: 0.967, 0.948–0.986 for OC and 0.986, 0.978–0.994 for PTH). No significant association was found between 25(OH)D and diabetes. Both OC and 25(OH)D, rather than PTH, were associated with abnormalities of high cholesterol levels, such as hypercholesterolemia and high LDL-C levels. Further classifying the population based on the median value of OC and PTH, low OC and low PTH subgroup had the highest OR, 95% CI for diabetes (1.873, 1.287–2.737) and the lowest OR, 95% CI for hypercholesterolemia (0.472, 0.324–0.688) and for high LDL-C (0.538, 0.376–0.771). Conclusion Among Chinese postmenopausal women, a lower serum level of OC was associated with a higher prevalence of diabetes and lower serum cholesterol levels, and a low PTH concentration could magnify these associations.
Highlights
Osteocalcin (OC) is a small noncollagenous protein secreted by the osteoblasts and an indicator of osteoblast activity [1]
In order to investigate the associations between glucose, lipid, bone, and vitamin D metabolism among women with natural menopause, we excluded woman coincided with one of these criteria: (1) she still had intermittent menstruation or her menstruation stopped after she took an operation of hysterectomy; (2) she was previously or currently treated with antidiabetic drugs, insulin, lipid-lowering drugs, corticosteroid, anticonvulsant drugs, bisphosphonates, calcitonin, estrogen, or progesterone; (3) she was currently supplemented with vitamin D in a daily dose above 10 mcg or supplemented with activated vitamin D; (4) her serum level of creatinine was over the upper limit of normal, or her serum level of alanine aminotransferase was higher than two times the upper limit of normal; and (5) her record of osteocalcin was lack
Compared to women with high OC levels, serum levels of all the cholesterol parameters (TC, high-density lipoprotein cholesterol (HDL-C), and LDL-C) were decreased and serum level of TG was increased in women with low OC levels
Summary
Associations between Osteocalcin, Calciotropic Hormones, and Energy Metabolism in a Cohort of Chinese Postmenopausal Women: Peking Vertebral Fracture Study. We examined the association between OC and energy metabolism among Chinese postmenopausal women. A logistic regression model was used to investigate the association of OC, PTH, or 25(OH)D with the prevalence of diabetes and dyslipidemia. No significant association was found between 25(OH)D and diabetes Both OC and 25(OH)D, rather than PTH, were associated with abnormalities of high cholesterol levels, such as hypercholesterolemia and high LDL-C levels. Among Chinese postmenopausal women, a lower serum level of OC was associated with a higher prevalence of diabetes and lower serum cholesterol levels, and a low PTH concentration could magnify these associations
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