Associations between Nine Polymorphisms in EXO1 and Cancer Susceptibility: A Systematic Review and Meta-Analysis of 39 Case-control Studies.

Meng Zhang,Li Zhang,Duran Zhao,Cunye Yan,Chaozhao Liang

doi:10.1038/srep29270

Abstract

An increasing number of studies have highlighted the potential link between EXO1 polymorphisms and cancer risk, although no consensus has yet been obtained. Thus, we aimed to obtain a thorough and current assessment of EXO1 polymorphisms and cancer susceptibility by performing a meta-analysis. A comprehensive literature retrieval was performed on PubMed, EMbase, Web of Science and Wanfang databases. The odds ratio (OR) and 95% confidence interval (CI) were applied to assess the results. Finally, 39 case-control studies of the nine EXO1 polymorphisms that involved 21,651 cases and 21,348 controls met our inclusion criteria. The pooled analysis indicated that the rs1047840 polymorphism conferred a significantly increased susceptibility to cancer in an allelic model. Similarly, the rs3754093, rs1776177, rs9350, rs10802996, rs1635498, rs1776148 and rs851797 polymorphisms were also associated with an increased susceptibility to cancer in an allelic model, respectively, while no significant association was identified for rs1635517 polymorphism. For the rs1047840 polymorphism, in an ethnicity subgroup analysis, a significantly increased susceptibility to cancer for Asians was identified in all the genetic models, and for Caucasians in an allelic model. Our findings provide the evidence that the rs1047840, rs9350, rs10802996, rs1635498, rs1776148, rs1776177, rs3754093 and rs851797 polymorphisms may act as risk factors for cancer.

Highlights

An increasing number of studies have highlighted the potential link between Exonuclease 1 (EXO1) polymorphisms and cancer risk, no consensus has yet been obtained
The detailed inclusion criteria were as follows: 1) the study was a case-control study; 2) the study evaluated the association between EXO1 polymorphisms and cancer susceptibility; 3) the study comprised useful allele and genotype frequencies to estimate the crude odds ratio (OR) at 95% confidence interval (CI)
After reading the title or abstract, 41 studies concerning the associations of the nine EXO1 polymorphisms and cancer susceptibility were selected for further consideration

Summary

Introduction

An increasing number of studies have highlighted the potential link between EXO1 polymorphisms and cancer risk, no consensus has yet been obtained. We aimed to obtain a thorough and current assessment of EXO1 polymorphisms and cancer susceptibility by performing a metaanalysis. The pooled analysis indicated that the rs1047840 polymorphism conferred a significantly increased susceptibility to cancer in an allelic model. For the rs1047840 polymorphism, in an ethnicity subgroup analysis, a significantly increased susceptibility to cancer for Asians was identified in all the genetic models, and for Caucasians in an allelic model. Susceptibility genes, including EXO12, have been found to play a key role in the initiation of cancer. An EXO1 polymorphism at codon 589 (rs1047840) is a non-synonymous single nucleotide polymorphism (SNP) that has been associated with susceptibility to lung cancer (LC)[5,6,7], glioma[8], breast cancer (BC)[9], and gastric cancer (GC)[10] As such, it may be a novel useful marker for primary tumour prevention and anticancer interventions. Correspondence and requests for materials should be addressed to L.Z

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