Associations between neutrophil-to-lymphocyte/platelet-to-lymphocyte and recovery in sudden sensorineural hearing loss.

Abstract

Aims: This study investigated the nonlinear associations between neutrophil-to-lymphocyte(NLR)/platelet-to-lymphocyte(PLR) and recovery rates in sudden sensorineural hearing loss(SSNHL). Methods: Total of 244 SSNHL patients were included. The primary outcome was recovery rate. Results: A nonlinear association was detected between NLR and recovery rate usingtheLOWESS method, with a knot of 3. Patients with NLR ≥3 had ahigher recovery rate than NLR <3. Using thelinear-spline function, NLR was significantly associated with high recovery rate when NLR was<3. However, when NLR was≥3, this association became nonsignificant. The trend test showed asimilar result. PLR was not associated with recovery rate. Conclusion: The association between NLR and recovery rate is nonlinear, with a knot of around three. PLR is not associated with recovery rate.