Associations between metabolic syndrome and clinical benign prostatic hyperplasia in a northern urban Han Chinese population: A prospective cohort study.

Si-Cong Zhao,Ming Xia,Yong Yan,Jian-Chun Tang

doi:10.1038/srep33933

Si-Cong Zhao, Ming Xia + Show 2 more

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https://doi.org/10.1038/srep33933

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Abstract

Biologic rationales exist for the associations between metabolic syndrome (MetS) and benign prostatic hyperplasia (BPH). However, epidemiologic studies have yield inconsistent results. The aim of the present study was to prospectively evaluate the associations of MetS with the risk of BPH. The presence of MetS, the number of MetS components, and the individual MetS components were evaluated. After adjusting for potential confounders, MetS was associated with increased risk of BPH (HR: 1.29; 95% CI, 1.08–1.50; p < 0.001). Compared with subjects without any MetS components, the HRs were 0.88 (95% CI, 0.67–1.09; p = 0.86), 1.18 (95% CI, 0.89–1.47; p = 0.29) and 1.37 (95% CI, 1.08–1.66; p = 0.014) for subjects with 1, 2, or ≥3 MetS components, and there was a biologic gradient between the number of MetS components and the risk of BPH (p-trend < 0.001). Central obesity and low high-density lipoprotein cholesterol were the two main divers of the associations between these two conditions, with HRs of 1.93 (95% CI, 1.14–2.72; p = 0.001) for central obesity, and 1.56 (95% CI, 1.08–2.04; p = 0.012) for low HDL-C. Our findings support the notion that MetS may be an important target for BPH prevention and intervention.

Highlights

Biologic rationales exist for the associations between metabolic syndrome (MetS) and benign prostatic hyperplasia (BPH)
Because emerging evidence indicates that a considerable number of modifiable risk factors such as obesity and lack of physical activity have an important role in the BPH etiology[2,3,4], it is increasingly recognized that BPH could partly be a preventable disease[5]
There were several studies reporting the association between MetS and BPH and/or its related lower urinary tract symptoms (LUTS), most of these studies used a cross-sectional design based on data collected at a certain time point and have yielded inconsistent results

Summary

Introduction

Biologic rationales exist for the associations between metabolic syndrome (MetS) and benign prostatic hyperplasia (BPH). Because emerging evidence indicates that a considerable number of modifiable risk factors such as obesity and lack of physical activity have an important role in the BPH etiology[2,3,4], it is increasingly recognized that BPH could partly be a preventable disease[5]. These findings highlighted that a cost-effective way for addressing BPH could be to intervene with these modifiable risk factors before disease development or treatment becomes necessary. Given the epidemic of MetS, if MetS does increase the risk of BPH, realization and utilization of their associations would have profound implications in decreasing the public health burden of BPH

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