Associations between Maternal Exposure to Bisphenol A or Triclosan and Gestational Hypertension and Preeclampsia: The MIIREC Study

Abstract

Background: Little is known about the association between bisphenol A (BPA) or triclosan (TCS) exposure and hypertension in pregnancy.Objective: To investigate potential associations between maternal urinary concentrations of BPA or TCS and gestational hypertension and preeclampsia.Methods: Among 1909 pregnant women participating in the (Maternal-Infant Research on Environmental Chemicals (MIREC) Study, urinary concentrations of BPA and TCS were measured in the first trimester by liquid chromatography-tandem mass spectrometry using isotope dilution. Blood pressure was measured during each trimester. Multinomial regression was performed to estimate the adjusted odds ratio (aOR) and 95% confidence intervals (CI) for the associations between these phenols and gestational hypertension and preeclampsia.Results: BPA urinary concentrations were similar according to hypertension status: the median (interquartile range) concentrations were 0.97 µg/L (0.40, 2.00), 1.10 µg/L (0.40, 1.90), and 0.80 µg/L (0.35, 1.70) for women with gestational hypertension, those with preeclampsia and normotensive women, respectively (p = 0.075). For TCS, the values were 10.04 µg/L (2.56, 76.26) for the group with gestational hypertension, 6.48 µg/L (1.48, 67.94) for those with preeclampsia and 8.56 µg/L (2.16, 67.35) for normotensive women (p = 0.559). Compared with the lowest tertile, BPA and TCS were not associated with gestational hypertension (aOR for BPA > 1.30 µg/L = 1.00; 95% CI: 0.54-1.81 and aOR for TCS > 32.6 µg/L = 1.41; 95% CI: 0.83-2.37) or preeclampsia (aOR for highest tertiles were 1.26; 95% CI: 0.53-2.97 and 0.68; 95% CI: 0.31-1.48, respectively). Conclusion: BPA and TCS urinary concentrations measured during the first trimester of pregnancy were not associated with gestational hypertension or preeclampsia. Additional studies are required to confirm our results.