Abstract
Wilms’ tumor is the most common childhood renal malignancy. A genome-wide association study identified LIM domain only 1 (LMO1) as having oncogenic potential. We examined the associations between LMO1 gene polymorphisms and susceptibility to Wilms’ tumor. In this hospital-based, case-control study, we recruited 145 children with Wilms’ tumor and 531 cancer-free children. Four polymorphisms (rs110419 A>G, rs4758051 G>A, rs10840002 A>G and rs204938 A>G) were genotyped using Taqman methodology. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure the associations between selected polymorphisms and Wilms’ tumor susceptibility. Only rs110419 AG was found to be protective against Wilms’ tumor (adjusted OR = 0.62, 95% CI = 0.41–0.94, P = 0.024) when compared to rs110419 AA. Wilms’ tumor risk was markedly greater in children with 1–4 risk genotypes (nucleotide alterations) than in those with no risk genotypes (adjusted OR = 1.84, 95% CI = 1.25–2.69, P = 0.002). In a stratified analysis, the protective effect of rs110419 AG/GG was predominant in males. The association of 1–4 risk genotypes with Wilms’ tumor risk was limited to subgroups of children who were >18 months old, female, and in clinical stages III+IV. Thus, LMO1 gene polymorphisms may contribute to Wilms’ tumor risk, but this conclusion should be validated in other populations and larger studies.
Highlights
Wilms’ tumor, known as nephroblastoma, is the most common renal malignancy in children [1, 2]
We examined the associations between LIM domain only 1 (LMO1) gene polymorphisms and susceptibility to Wilms’ tumor
Numerous subsequent studies have demonstrated the association of this critical gene with neuroblastoma risk [29,30,31], none have investigated the associations between LMO1 single nucleotide polymorphisms (SNPs) and Wilms’ tumor risk
Summary
Wilms’ tumor, known as nephroblastoma, is the most common renal malignancy in children [1, 2]. Dramatic progress has been made in the treatment of children with Wilms’ tumor, with overall survival rates exceeding 90% in 2009, compared with about 30% in the 1930s [5, 6]. Numerous subsequent studies have demonstrated the association of this critical gene with neuroblastoma risk [29,30,31], none have investigated the associations between LMO1 single nucleotide polymorphisms (SNPs) and Wilms’ tumor risk. Four polymorphisms in LMO1 (rs110419 A>G, rs4758051 G>A, rs10840002 A>G and rs204938 A>G) were found to be associated with the risk of several cancers in a genome-wide association study (GWAS) [29, 32] We speculated that these polymorphisms might contribute to the risk of Wilms’ tumor. We examined the associations between these LMO1 polymorphisms and Wilms’ tumor risk in Southern Chinese children
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