Abstract
The oxidative stress biomarker of urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) was reported to be changed in patients with allergic diseases. Measurement of urinary oxidative products is noninvasive. However, correlations between the severity levels of atopic diseases and oxidative stress remain unclear. This study aimed to investigate the association among urinary 8-OHdG, atopic dermatitis (AD), and the phenotypes of atopic diseases in children. In a nested case-control study, participants of kindergarten children were enrolled from the Childhood Environment and Allergic Diseases Study (CEAS). Urinary analyses and urinary 8-OHdG were performed on samples from 200 children with AD as cases and 200 age- and sex-matched controls. Our study presents the following main findings: (1) The urinary 8-OHdG levels were significantly higher in cases than controls. Higher urinary 8-OHdG levels were associated with the risk of AD in a dose-response-manner; (2) Children’s AD history was associated with higher risks of asthma, allergic rhinitis, and night pruritus; (3) For children with AD, urinary 8-OHdG levels of >75th percentile were associated with higher risk of asthma, compared with the reference group of 0–25th percentiles. In summary, this study provides better understanding of the underlying mechanisms of AD and urinary 8-OHdG by analyzing a large-scale sample survey in Taiwan.
Highlights
Atopic diseases frequently present with the onset of atopic dermatitis (AD), asthma, pruritus, and allergic rhinitis, with significant costs to patients and their families and adverse effects on patients’quality of life
The distributions of age, sex, premature birth (
AD children with higher urinary 8-OHdG levels >42.7 ng/mg Cr, >75th percentiles) were significantly associated with asthma as compared with reference group of urinary 8-OHdG
Summary
Atopic diseases frequently present with the onset of atopic dermatitis (AD), asthma, pruritus, and allergic rhinitis, with significant costs to patients and their families and adverse effects on patients’quality of life. Atopic diseases frequently present with the onset of atopic dermatitis (AD), asthma, pruritus, and allergic rhinitis, with significant costs to patients and their families and adverse effects on patients’. AD is a chronic and relapsing inflammatory skin disease, which is associated with increased serum Immunoglobulin E (IgE) levels and tissue eosinophilia [1]. AD has been classified into three phases: infantile, childhood, and adult; each phase can be characterized with various physical findings [3]. AD affects more than 10% of children at some point during childhood [4]. AD is a chronic inflammatory disease of the skin, which often precedes asthma and other atopic diseases including asthma and allergic rhinitis, i.e., the so-called “atopic march” [5]
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