Abstract
This case-control study aimed to investigate potential associations between interleukin (IL) gene polymorphisms and the risks of developing extremity posttraumatic osteomyelitis (PTOM) in Chinese Han population. Altogether, 189 PTOM patients and 200 healthy controls were genotyped of IL-1α (rs17561, rs1800587), IL-1β (rs16944, rs1143627, rs1143634, rs2853550), IL-1RN (rs4251961, rs419598, rs315951), IL-4 (rs2243248, rs2243250), IL-6 (rs1800795, rs1800796, rs1800797), IL-8 (rs4073, rs2227306, rs2227307), IL-10 (rs3024491, rs3024496, rs1800871, rs1800872, rs1800896), IL-17A (rs2275913), and IL-17F (rs763780) using the SNaPshot genotyping method. Statistical differences were observed regarding the genotype distributions of rs16944 (P = 0.049) and rs4251961 (P = 0.007) between the patients and healthy controls. In addition, significant associations were found between rs16944 and the risk of PTOM development by dominant (OR = 1.854, P = 0.017), homozygous (OR = 1.831, P = 0.041), and heterozygous (OR = 1.869, P = 0.022) models, and of rs1143627 by dominant (OR = 1.735, P = 0.032) and homozygous (OR = 1.839, P = 0.040) models. Moreover, significant links were also identified between rs4251961 and the susceptibility to PTOM by dominant (OR = 0.446, P = 0.005) and heterozygous (OR = 0.409, P = 0.003) models, and of rs1800796 by dominant (OR = 4.184, P = 0.029), homozygous (OR = 4.378, P = 0.026), and heterozygous (OR = 3.834, P = 0.046) models. The present outcomes demonstrated that rs16944, rs1143627, and rs1800796 associate with increased risks, while rs4251961 links to a decreased risk of PTOM development in Chinese Han population.
Highlights
Posttraumatic osteomyelitis (PTOM) refers to osseous infection with or without surrounding soft tissue infection following trauma and orthopaedic surgery
The accurate diagnosis and successful treatment of PTOM remain challenging in front of clinicians, which primarily attributes to its “wide spectrum” or “high heterogeneity” characteristics
All the genotyped 24 IL gene single nucleotide polymorphisms (SNPs) were in Hardy-Weinberg equilibrium (HWE) for healthy controls (P > 0:05) (Table S2)
Summary
Posttraumatic osteomyelitis (PTOM) refers to osseous infection with or without surrounding soft tissue infection following trauma and orthopaedic surgery. It is estimated that the incidence of PTOM ranged between 0.4% and 16.1% [1], with 1% to 2% after closed fractures, and up to 30% following open fractures [2], with the highest rate of 55% [3]. Clinical efficacy and prognosis are influenced by multiple factors, such as bone location, infection range and duration, pathogen type and virulence, and treatment strategy. How to lower the incidence is as important as the topic of how to improve the cure rate. To achieve this goal, it is essential to comprehensively understand PTOM pathogenesis, which associates with both environmental and host factors
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
