Associations between interleukin 1 polymorphisms and susceptibility to systemic lupus erythematosus: A meta-analysis

Abstract

ObjectiveThis study determined whether interleukin 1 (IL1) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE). MethodsA meta-analysis was conducted on the associations between the IL1A, IL1B, and IL1 receptor antagonist (IL1RN) polymorphisms and SLE. ResultsA total of 15 studies involving 1956 SLE cases and 2347 controls were included in the meta-analysis. The meta-analysis showed an association between SLE and the IL1A −889 T allele in the overall population and Europeans (OR=0.858, 95% CI=0.737–0.986, p=0.032; OR=0.827, 95% CI=0.687–0.994, p=0.043). Meta-analysis of the IL1RN polymorphism revealed an association with SLE in all study subjects (OR for IL1RN∗2=1.539, 95% CI=1.266–1.871, p=1.5×10−2) and in Europeans and Asians (OR=1.483, 95% CI=1.187–1.852, p=0.001; OR=1.787, 95% CI=1.167–2.736, p=0.008). No associations were found between SLE and the IL1B −511 C/T, 3953 C/T, and IL1A +4845 G/T polymorphisms. ConclusionsThis meta-analysis suggests IL1A −889 C/T polymorphism is associated with susceptibility to SLE in Europeans, and that the IL1RN∗2 allele is associated with susceptibility to SLE in Europeans and Asians.