Associations between interleukin 1β gene polymorphism -511C/T, -31T/C and depressive disorders in Uygur population of Xinjiang

Abstract

Objective To explore the distribution on -511C/T, -31T/C single nucleotide polymorphism of IL-1β gene among Uygur population in Xinjiang, and to analyze the correlation between IL-1β gene polymorphism and depressive disorders. Methods A total of 100 patients with depressive disorders and 120 control subjects were selected. Polymerase chain reaction and restriction fragment length polymorphism (RFLP-PCR), enzyme digestion and sequence reaction were used to detect the common -511C/T, -31T/C polymorphism of the IL-1β gene. The relationship between the polymorphism in the IL-1β gene and the severity of depressive disorders was analyzed. Results The frequencies of CC, CT, TT in -511 were 19.0%, 58.0% and 23.0% in patient group, while those were 19.2%, 55.0%, 25.8% in the control group, which did not show statistically significant differences (χ2=0.266, P=0.875). The frequencies of CC, CT, TT in -31 were 24.0%, 58.0% and 18.0%in the patient group, while those were 24.2%, 58.3%, 17.5% in the control group, which did not show statistically significant differences (χ2=0.0093, P=0.995). The frequencies of CC, CT, TT genotypes of the IL-1β gene polymorphism(-511C/T, -31T/C) were not statistically different between depressive patients and healthy controls. Conclusion The findings suggest no significant association between -511C/T, -31T/C polymorphism and depressive disorders in Uygur population of Xinjiang. Key words: Depressive disorders; Interleukin-1 Beta; Single nucleotide polymorphism; Uygur