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Abstract
Background: Over the last two decades, many studies have investigated the association between interleukin 6 (IL-6) and pathogenesis and progression of coronary artery disease (CAD). Patients with CAD manifested at a young age are a particularly interesting group. They differ from older patients, not only in terms of the severity of coronary artery atherosclerosis, but also risk factor profiles, short- and long-term prognosis after myocardial infarction (MI). The role of IL-6 in younger patients with CAD is less well-known. Therefore, our study aimed to analyze the relationship between IL-6 level and other inflammations, atherosclerosis, and cardiac function parameters in early onset CAD patients. Methods: The study covered 100 patients with early onset CAD and a group of 50 healthy participants. Plasma levels of IL-6 and basic biochemical parameters, anthropometric, echocardiographic, and arteries Doppler ultrasound measurements were performed. Results: We did not observe a significant difference in IL-6 concentration in plasma between patients with early onset CAD and a control group, but IL-6 level was negatively correlated with echocardiographic measurements of ascending aorta diameter, left ventricular shortening fraction, and right ventricular end-diastolic diameter in our patients. Conclusions: In patients with early onset CAD, plasma IL-6 level is associated with other inflammation parameters and with cardiac function, potentially contributing to right ventricular remodeling and left ventricular systolic dysfunction. This suggests possible prognostic benefits of long-time observation of IL-6 level after the acute coronary syndrome.
Highlights
Coronary artery disease (CAD) has become a major public health challenge
The measurements were followed by the calculations of the body mass index (BMI), waist-to-hip ratio (WHR), and mean arterial pressure (MAP)
Negative correlations (p < 0.05) were demonstrated between interleukin 6 (IL-6) and mean corpuscular hemoglobin concentration (MCHC), echocardiographic measurements of ascending aorta diameter, left ventricular shortening fraction, right ventricular end-diastolic diameter, and Intima-media complex thickness (IMC) left brachial artery performed in the whole study group and in the subgroup of males and the subgroup post-myocardial infarction (MI)
Summary
Coronary artery disease (CAD) has become a major public health challenge. It is related to high morbidity and mortality worldwide and it is increasingly prevalent in the Western world [1]. About 170,000 people die from cardiovascular disease in Poland, which is 47% of all deaths [2] This disorder usually affects the elderly, an increasing prevalence of CAD among younger people has been observed over the last few decades. A past myocardial infarction (MI), diabetes, smoking, and lower ejection fraction predict a significantly higher mortality Better knowledge of this group of patients is important in the era of preventive cardiology. Does IL-6 take part in the pathogenesis of CAD, and its levels can be affected by CAD and its consequences This cytokine is a promising noninvasive marker for monitoring patients with CAD before and after acute coronary syndrome. The present study aimed to analyze the relationship between IL-6 level and other inflammations, atherosclerosis, and cardiac function parameters in early onset CAD patients
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