Abstract
The purpose of this study was to determine the associations between urinary estradiol (E2) metabolite concentration and medial knee loading with radiographic disease severity in middle aged women with initial stage knee osteoarthritis (OA). Women presenting with knee pain were recruited into a cross-sectional correlation study (KOA, n = 9, age = 52 ± 4 yrs). Self report menstrual history, the Modified Baecke Questionnaire and the Knee Injury and Osteoarthritis Outcome Score (KOOS) subjective data were collected. A fasting blood sample (follicle stimulating hormone (FSH) and Tumor Necrosis Factor-α (TNF-α)), and urine catch (16α-hydroxyestrone and 2-hydroxyestrone) were collected. Gait analysis using an 8-camera motion analysis system assessed internal knee varus moment and foot progression angle. Pearson Product moments tested for associations between urinary 16α-hydroxyestrone and 2-hydroxyestrone, TNF-α, medial knee loading, and radiographic disease severity (Kellgren/Lawrence (K/L) radiographic score). Significant correlations were found within the hormonal biomarkers (r = 0.94, p p p = 0.31). No correlations were found for radiographic disease severity or TNF-α. The lack of association between hormonal and biomechanical variables could be due to large variability of the E2 metabolites seen in the menopause transition and the limited structural changes of initial staged knee OA.
Highlights
The purpose of this study was to determine the associations between urinary estradiol (E2) metabolite concentration and medial knee loading with radiographic disease severity in middle aged women with initial stage knee osteoarthritis (OA)
Pearson Product moments tested for associations between urinary 16α-hydroxyestrone and 2-hydroxyestrone, Tumor Necrosis Factor-α (TNF-α), medial knee loading, and radiographic disease severity (Kellgren/Lawrence (K/L) radiographic score)
One of the leading causes of disability in the elderly is the pain associated with knee osteoarthritis (OA) [1]
Summary
One of the leading causes of disability in the elderly is the pain associated with knee osteoarthritis (OA) [1]. Chronic pain from knee OA can decrease physical activity, increasing the risk for: chronic disease, decreased functional independence and diminished quality of life [2]. Urinary estradiol (E2) metabolites were shown to be associated with the incidence of knee OA in perimenopausal women, possibly due to regulation of arachidonic acid metabolism [4]. Greater knee loading across the medial compartment during walking has been shown to predict medial knee OA progression [5,6,7]. It may be possible to ascertain the influence of E2 in the etiology of knee OA by tracking its association across time to the established pathomechanic marker of medial knee loading
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
