Associations between HIF-1α polymorphisms C1772T and G1790A and susceptibility to chronic obstructive pulmonary disease.

Abstract

In the present study, we examined whether hypoxia-inducible factor-1α (HIF-1α) polymorphisms are associated with the susceptibility to chronic obstructive pulmonary disease (COPD). One hundred and twenty patients with COPD and 112 healthy controls were recruited from the Han population in Southern China. Polymerase chain reaction-restriction fragment length polymorphism was used to assess the C1772T and G1790A polymorphisms in the HIF-1α gene, and differences in genotypes between the 2 groups were compared. No significant difference in the distribution of the C1772T polymorphism was observed between COPD cases and healthy controls (P > 0.05). In contrast, the distribution of the G1790A polymorphism was significantly different between the 2 groups (P < 0.05). Our results indicated that the HIF-1α G1790A polymorphism was associated with an increased susceptibility to COPD in Han subjects from Southern China.